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The Borgias' favourite method of administering a lethal dose was by means of a species of hypodermic injection.

A document drawn up by Charles, King of Navarre, throws some light on the systematic manner in which the poisoning of obnoxious persons was carried out in mediaeval times. It is in the form of a commission to one Wondreton to poison Charles VI, the Duke of Valois, brother of the King, and his uncles, the Dukes of Berri, Burgundy, and Bourbon. It runs: "Go thou to Paris; thou canst do great service if thou wilt. Do what I tell thee; I will reward thee well. There is a thing which is called sublimed arsenic; if a man eat a bit the size of a pea, he will never survive. Thou wilt find it in Pampeluna, Bordeaux, Bayonne, and in all the good towns thou wilt pass at the apothecaries' shops. Take it, and powder it; and when thou shalt be in the house of the King, of the Count de Valois his brother, and the Dukes of Berri, Burgundy, and Bourbon, draw near and betake thyself to the kitchen, to the larder, to the cellar, or any other place where thy point can best be gained, and put the powder in the soups, meats, or wines; provided that thou canst do it secretly. Otherwise do it not." It is satisfactory to learn that the miscreant who was intrusted with this diabolical commission, was detected in time, and executed in 1384.

There is an old tradition that King John also figured as a poisoner, and got rid of the unfortunate Maud Fitz-Walter by means of a poisoned egg. The story is a romantic one, and is related by Hepworth Dixon in "Her Majesty's Tower." "In the reign of King John, the White Tower received one of the first and fairest of a long line of female victims, in that of Maud Fitz-Walter, who was known to the singers of her time as Maud the Fair. The father of this beautiful girl was Robert, Lord Fitz-Walter, of Castle Baynard, on the Thames, one of John's most powerful and greatest barons. Yet the King, during, it is said, a fit of violence or temper with the Queen, fell madly in love with the fair Maud. As neither the lady herself nor her powerful sire would listen to his disgraceful suit, the King is said to have seized her by force at Dunmow and brought her to the Tower. Fitz-Walter raised an outcry, on which the King sent troops into Castle Baynard and his other houses, and when the baron protested against these wrongs, his master banished him from the realm. Fitz-Walter fled to France with his wife and other children, leaving poor Maud in the Tower, where she suffered a daily insult in the King's unlawful suit. But she remained obdurate, and refused his offers. On her proud and scornful answer to his overtures being heard, John carried her up to the roof and locked her in the round turret, standing on the north-east angle of the keep. Maud's cage was the highest and chilliest den in the Tower; but neither cold, solitude, nor hunger could break her strength, and at last, in the rage of his disappointed love, the King sent one of his minions to her room with a poisoned egg, of which the brave girl ate and died."

Bluff King Hal at one period of his life was apprehensive of being poisoned, and it was commonly believed that Anne Boleyn attempted to dose him. It is recorded that the King, in an interview with young Prince Henry, burst into tears, saying that he and his sister, the Princess Mary, might thank God for having escaped from the hands of that accursed and venomous harlot, who had intended to poison them.

According to the French Chronicles, "After the death of Gaultier Giffard, Count Buckingham, in the early part of the twelfth century, Agnes his widow became enamoured with Robert Duke of Normandy and attached herself in an illicit manner to him, shortly after which time his wife Sibylle died of poison."

Pope Alexander VI and his son the Duke Valentinois employed arsenic to carry out their fiendish plans, not only on their enemies, but their friends also. Thus perished by their hands the Cardinals of Capua and Modena; and Alexander himself by a cup intended for Adrian, Cardinal of Corneto, who had invited the pope to a banquet in the Vineyard of Belvedere, was destroyed instead of his host.

Lucretia Borgia, famous in romance and song for her poisoning propensities, was a daughter of Pope Alexander VI, and sister of Cesare Borgia. She married Giovanni Sforza, Lord of Pesaro, in 1493, but being a woman of haughty disposition and evil temper, their life was anything but a happy one; and after living together for four years, Alexander dissolved the marriage, and gave her to Alphonso II of Naples. Two years had barely passed before her second husband was assassinated by hired ruffians of Cesare Borgia. So Lucretia took unto herself a third husband in the person of Alphonso d'Este, a son of the Duke of Ferrara. She led a wild and unhappy life, and was accused of poisoning, and almost every form of crime, although it is stated by several modern historians that many of these charges were unfounded. Although tradition has inflicted her with a bad character, she is said to have been a liberal patroness of art and literature in her time. She died in 1523.

In 1536 the Dauphin, eldest son of Francis I, died suddenly, and suspicion attached to Sebastian Montecucculi, a Ferrarese, who held the part of cup-bearer--bribed, as was supposed by Catherine of Medicis in order to secure the crown to her husband, Henry, Duke of Orleans, who became Dauphin in consequence of his elder brother's death.

The story of the Countess of Somerset, who was tried with others for the murder of Sir Thomas Overbury in the reign of James I, forms an interesting episode in the history of romantic poisoning. Robert, Earl of Essex, son of Queen Elizabeth's favourite, and who afterwards became Commander-in-chief of the Parliamentary forces, married, at the age of fourteen, Frances Howard, a younger daughter of the Earl of Suffolk, the bride being just a year younger than her husband. The match had been arranged and brought about through the influence of relatives, who thought it expedient that the youthful bridegroom should be sent off to travel on the Continent immediately after the marriage had taken place, and he remained away for three or four years. During this period the countess, who was brought up at court, developed into a very beautiful woman, but seems to have been equally unprincipled and capricious. On the return of the earl from his travels, she shrank from all advances on his part, and showed the utmost repugnance to her husband on all occasions. Their dispositions were entirely different. He loved retirement, and wished to live a quiet country life, while she, who had been bred at court, and accustomed to adulation and intrigue, refused to leave town. The King about this time had a number of young men of distinguished appearance and good looks attached to the court, and of these, one Robert Carr, at length became an exclusive favourite. Between him and the self-willed young countess there sprang up an attachment, which, at least on her side, amounted to infatuation. Her opportunities for meeting her lover were short and rare, and in this emergency she applied to a Mrs. Turner, who introduced her to Dr. Forman, a noted astrologer and magician at that time, and he, by images made of wax, and other devices of the black art, undertook to procure the love of Carr to the lady. At the same time he was also to practise against the earl in the opposite direction. These measures, however, were too slow for the wayward countess, and having gone to the utmost lengths with her inamorata, she insisted on a divorce, and a legal marriage with him.

One of Carr's greatest friends was Sir Thomas Overbury, a young courtier and a man of honour and kindly disposition. He was much against this intimacy, and besought his friend to break it off, assuring him it would ruin his prospects and reputation if he married the lady. Carr unwisely made this known to the countess, who at once regarded Overbury as a bitter enemy, and resolved to do what she could to overthrow him. The pair plotted together with evident success, for the unfortunate Sir Thomas was shortly afterwards committed to the Tower by an arbitrary mandate of the King; next, he was not allowed to see any visitors; and, finally, his food was poisoned, and, after several unsuccessful attempts on his life, he at last died from the effects of poison. Cantharides, nitrate of silver, spiders, arsenic, and last of all, corrosive sublimate, are said to have been administered in turn to this unfortunate individual. Meanwhile, the countess obtained a divorce from her husband on the ground of impotency, and married Carr, who was soon after made Earl of Somerset by King James.

Two years elapsed before the murder of Sir Thomas Overbury was brought to light, when the inferior criminals, Mrs. Turner and the others, were convicted and executed; but the Earl of Somerset and his countess, although found guilty with their accomplices, received the royal pardon. The happiness of the earl and countess, however, was not of long duration, as it is stated they afterwards became so alienated from each other, that they resided for years under the same roof with the most careful precautions that they might not by any chance come into each other's presence. The Mrs. Turner implicated in the crime is said to have been the first to introduce into England the yellow starch that was then applied to ladies' ruffs. Her last request was, that she should be hanged in a ruff dyed with her own yellow starch, which is said to have been carried out.

According to some historians, Robert Dudley, Earl of Leicester, Prime Minister and favourite of Queen Elizabeth, was a poisoner of the most diabolical description.

His ambition to marry his royal mistress, who, shrewd woman as she was, seems to have had no insight into his unscrupulous character, was the cause of his moving every human obstacle from his path by insidious methods. The murder of his wife Amy Robsart was the first of a long series of murders, carried out, doubtless, at his instigation. He was next suspected of causing the death of Lord Sheffield, of whose lady he was an admirer. The Earl of Essex is said to have been another victim. His death is described in the language of the time as having been due to "an extreme flux caused by an Italian Receit, the maker whereof was a surgeon that then was newly come to my Lord from Italy, a cunning man and sure in operation. The inventor of this recipe was known as one Dr. Julio, who was said to be able to make a man dye in what manner of sickness you will." The death of the Earl of Essex took place when on his way home from Ireland, with the object of revenging himself on the Earl of Leicester for his domestic wrongs. The next victim is said to have been Cardinal Chatillian, who, having accused the earl of preventing the marriage of the queen to the King of France, was journeying back to Dover, when he was taken suddenly ill and died in Canterbury.

Sir Nicholas Throgmorton, a wealthy city magnate and a tool of the earl's, whom, 'tis said, he used to thwart the doings of the Lord Treasurer, Sir William Cecil, was another victim. Having heard that Sir Nicholas was revealing some of his secrets, he invited him one night to supper at his house in London, and at supper time hurriedly went to the court, to which he said he had been called suddenly by her Majesty. Sir Nicholas proceeded with the meal in his absence, and soon after was seized with a violent vomiting, from which he never recovered. According to an old chronicler, "The day before his death he declared to a dear friend, all the circumstances and cause of his complaint, which he affirmed plainly to be poison given him in a sallet at supper, inveighing most earnestly against the earl's cruelty and bloody disposition, and affirming him to be the wickedest, most perilous and perfidious man under heaven."

The chronicler continues: "And for his art of poisoning, it is such now, and reaching so far, as he holdeth all his foes in England and elsewhere, as also a good many of his friends, in fear thereof, and if it were known how many he hath despatched in that way would be marvellous to posterity.

He is said to have kept in his employ several needy but unscrupulous physicians, ready to administer the "Italian Comfortive," as the poison was called, at his bidding. "With the Earl of Essex, one Mrs. Alice Drakott, a godly gentlewoman, is also said to have been poisoned." This lady happened to be accompanying the earl on her way towards her own house, when after partaking of the same cup she was also seized with violent pain and vomiting, which continued until she died, a day or two before the earl succumbed. "When she was dead," says the chronicler, "her body was swollen into a monstrous bigness and deformity; whereof the good earl, hearing the day following, lamented the case greatly, and said in the presence of his servants, 'Ah! poor Alice, the cup was not prepared for thee, albeit it was thy hard fortune to taste thereof.'"

PROFESSIONAL POISONERS

THE criminal destruction of life by poison has been practised from ancient times. Very little was known of toxicology in those days, and even the symptoms often passed unrecognised or were attributed to natural causes, and the poisoners' fiendish work was frequently undiscovered and rendered easy. In the early Christian era, poisoning, indeed, became quite a profession, and convenient individuals could be hired with little difficulty to administer a deadly dose to an enemy or rival. Agrippina, in refusing to eat some apples offered to her at table by her father-in-law Tiberius, must have had suspicions of this kind. Locusta, who is said to have supplied the poison by which Agrippina got rid of Claudius, and who also prepared the dose for Britannicus, according to the order of his brother Nero, is the first professional poisoner of whom we have record.

In the year B.C. 331 an epidemic broke out in Rome which was supposed to proceed from corrupt air, but it was observed that the principal patricians only were the victims. Their deaths, however, were attributed to infection, for poisoning was then scarcely known in Rome nor was there a law for its punishment. In the general grief, a female slave presented herself to the edile curule Q. Fabius and accused more than twenty Roman ladies of poisoning: designing specially Cornelia, a lady of an illustrious family of that name, and Sergia, another patrician lady. It is recorded that as many as three hundred and sixty-six ladies were similarly accused; but Cornelia and Sergia were detected in compounding their fatal potions. "When led before the popular assembly they maintained their preparations were harmless remedies. The slave, seeing herself accused as a false witness, asked that the ladies should be required to swallow their own potions; which they did, and by so doing avoided a more shameful death."

From the fifteenth to the seventeenth century two great criminal schools arose in Venice and Italy.

The Venetian poisoners who first came into notoriety, flourished in the fifteenth century. At that period the mania for poisoning had risen to such a height, that the governments of the states were formally recognizing secret assassination by poison, and considering the removal of emperors, princes, and powerful nobles by this method. The notorious Council of Ten met to consider such plans, and an account and record of their proceedings still exists, giving the number of those who voted for and who voted against the proposed removal, the reasons for the assassination, and the sum to be paid for its execution. Thus these conspirators quietly arranged to take the lives of many prominent individuals; and when the deed was executed, it was registered on the margin of their official record by the significant word "Factum." On December 15, 1543, John of Raguba, a Franciscan brother, offered the Council a selection of poisons, and declared himself ready to remove any person whom they deemed objectionable out of the way. He calmly stated his terms, which for the first successful case were to be a pension of 1,500 ducats a year, to be increased on the execution of future services. The Presidents, Guolando Duoda and Pietro Guiarini, placed this matter before the Council on January 4, 1544, and on a division, it was resolved to accept this patriotic offer, and to experiment first on the Emperor Maximilian. John, who had evidently reduced poisoning to a fine art, submitted afterwards a regular graduated tariff to the Council, which ran as follows--

For the great Sultan, 500 ducats.

For the King of Spain, 150 ducats, including the expenses of the journey, etc.

For the Duke of Milan, 60 ducats.

For the Marquis of Mantua, 50 ducats.

For the Pope, 100 ducats.

He further adds at the foot of the document, "The farther the journey, the more eminent the man, the more it is necessary to reward the toil and hardships undertaken, and the heavier must be the payment."

The school of Italian poisoners became prominent in the sixteenth and seventeenth centuries, and the magnitude of their operations during that period struck terror into the hearts of the chief nobles and rulers of that country.

Aqua Toffana was reputed to possess some very peculiar properties, and, among others, that of causing death at any determinate period, after months, for example, or even years of ill-health . Its alleged effects are graphically described by Behrens as follows: "A certain indescribable change is felt in the whole body, which leads the person to complain to his physician. The physician examines and reflects, but finds no symptoms either external or internal, no vomiting, no inflammation, no fever. In short, he can only advise patience, strict regimen, and laxatives. The malady, however, creeps on, and the physician is again sent for. Still he cannot detect any symptoms of note. Meanwhile the poison takes firmer hold of the system; languor, wearisomeness, and loathing of food continue; the nobler organs gradually become torpid, and the lungs in particular at length begin to suffer. In a word, the malady from the first is incurable; the unhappy victim pines away insensibly even in the hands of the physician, and thus is he brought to a miserable end through months or years, according to his enemy's desire."

Toffana had many imitators, and some time after her death a similar scheme was attempted with a poisonous solution reputedly sold as a cosmetic, called the "Acquetta di Perugia." It is said to have been prepared by killing a hog, disjointing it, strewing the pieces with white arsenic, which was well rubbed in, and finally collecting the juice which dropped from the meat itself. This preparation was supposed to be much stronger and a more powerful poison than arsenic itself, but doubtless had the same fatal effect.

It is a curious fact that most of the notorious poisoners in mediaeval times were women, and, indeed, in later years the frail sex seem to have retained a special predilection for this form of crime. In the year 1659, a secret society of women, most of whom were young wives belonging to some of the best and wealthiest families of Rome, was discovered in that city, the sole or chief object of which was to destroy the lives of the husbands of the members. They met at regular intervals at the house of one Hieronyma Spara, a woman reputed to be a witch, who provided her fellow associates and pupils with the required poison, and planned and instructed them how to use it. Operations had been carried on for some time, when the existence of the society was discovered and, says a chronicler, "the hardened old hag passed the ordeal of the rack without confession; but another woman divulged the secrets of the sisterhood, and La Spara, together with twelve other women implicated, were hanged." Many others who were guilty in a lesser degree were publicly whipped through the streets of the city.

She was eventually beheaded, and burnt near Notre Dame in July, 1676. St. Croix is said to have accidentally succumbed to the effects of poisonous fumes in his own laboratory. The authorities on examining his effects, as he left no family, came across a small box to which a paper was attached, which contained a request that after his death "it might be delivered to the Marquise de Brinvilliers, who resides in Rue Neuve St. Paul." This paper was signed and dated by St. Croix on May 25, 1672. On the box being opened, it was found to contain a large collection of various poisons, including corrosive sublimate, antimony, and opium. When the marquise heard of the death of her lover, she at once made every effort to obtain the box by bribing the officers of justice, but failed. La Chauss?e, the servant of St. Croix, laid claim to the property, but was arrested as an accomplice and imprisoned. On confessing many serious crimes he was broken alive on the wheel in 1673. Evidence was brought to prove at the trial of De Brinvilliers, that both she and St. Croix were secretly combined with other persons accused of similar crimes. Some distinguished people were implicated, including Pennautier, the receiver-general of the clergy, who was afterwards accused of practising her secrets. One crime seemed to bring another to light, and two persons, named La Voisin and La Vigoreux, a priest named Le Sage, and several others, were next haled before the tribunal, and charged with trading with the secrets of Exili and inciting people with weak minds to the crime of poisoning. It was alleged that through their instrumentality a large number of married women had hastened the decease of their husbands.

The Chambre Ardente, or Burning Court, as it was commonly called, was established at the Arsenal, near the Bastille, and was rarely idle. Persons of the highest rank were cited to appear before it; among others, two nieces of Cardinal Mazarin, the Duchess of Bouillon, and the Countess de Soissons, mother of Prince Eug?ne. The Countess de Soissons had to retire to Brussels.

The Marshal de Luxemburg was the next sensational arrest. He was carried to the Bastille and submitted to a long examination, after which he was allowed to remain fourteen months in prison. La Voisin and his accomplices were eventually condemned and burnt at the stake, which seemed to put a check on this series of abominable crimes which spread throughout France from 1670 to 1680.

The "poudre de succession," famous in Paris as a secret poison, was at one time supposed to consist of diamond dust, but, according to Haller, was really composed of sugar of lead. This was used by several notorious criminals during the seventeenth century.

POISONING PLOTS

THE use of poison as an instrument for political purposes during the Middle Ages soon spread over Europe, and the dread of wholesale poisoning caused numerous panics. Some of these alarms may probably have been circulated by unscrupulous traders who had articles to sell, or some business interest to forward, but of others authentic records exist.

June 6 is still kept as a public holiday in Malta. Upon that day, a century and a half ago, while the island was still possessed by the Knights of St. John, a Jew waited on the Grand Master, and revealed to him a plot that had been planned for exterminating the whole population at a stroke. This man kept a coffee house frequented by the Turkish slaves, and understanding their language, he had overheard suspicious remarks among his customers. The Grand Master, believing the truth of the man's statement, took immediate action. The slaves indicated were at once seized and put to torture, and they confessed a design of poisoning all the wells and fountains on the island, and to make the result surer, each of the conspirators was to assassinate a Christian. One hundred and twenty-five were found guilty. Some were burnt, some broken on the wheel, while others were ordered to have their arms and legs attached to two galleys which, on being rowed apart, would thus dismember them. Whether these frightful punishments were carried out it is impossible to say, but the fact remains that the people of Malta still commemorate their escape from poisoning to the present time.

Wholesale poisoning appears to have been a common practice in Eastern countries, especially in India and Persia. The wells or other water sources were usually chosen as the medium for disseminating the poison, and in this way whole villages have often been destroyed by some miscreant. Another extraordinary poisoning plot was discovered in Lima towards the close of the eighteenth century. During the insurrection of 1781, a rich Cacique, who professed loyalty, went to a chemist's shop and asked for 200 lb. of corrosive sublimate. He was willing to pay any price. The chemist had not anything like that amount in stock, and not wishing to send such a good customer away, substituted 200 lb. of alum. On the following day all the water in the town was found to be impregnated with alum. An examination being made of the reservoir, it was found that the fence round it had been broken down and the banks strewn with alum, and the water rendered undrinkable.

England has remained practically free from crimes of this kind. In 1530, a case occurred which caused great public indignation. Fisher, Bishop of Rochester, was accustomed to entertain a number of poor people daily. One afternoon a large number of his humble guests, together with some of the officers of the household, were taken ill. Two died, and after an examination of the food had been made, it was declared the yeast had been poisoned. Parliament took up the investigation, and the bishop's cook, one Richard Rowe, was found guilty. He was tried, and sentenced to be boiled alive as a terrible example to others. Boiling seems to have been a favourite punishment for poisoners during the Middle Ages, a fact which, doubtless, shows the abhorrence in which crimes of this kind were held.

It is further recorded that "On March 17th, 1524, Margaret Davy, maid, was boiled in Smithfield for poisoning three households she had dwelled in."

Among Queen Elizabeth's statesmen, poison would appear to have been regarded as almost a legitimate weapon of defence. Her favourite Leicester, to whom we have already alluded, was often called "The Poisoner." This propensity was probably largely due to the fact that most young Englishmen of rank were sent to Italy to finish their education, and there were introduced to the Italian methods of poisoning so much in vogue.

The Duc de Guise, in his memoirs, relates in a most matter-of-fact way, how he requested the captain of his guard to poniard a troublesome demagogue at Naples. The captain was shocked. He would poison any one at his Grace's command with pleasure, but the dagger was a vulgar instrument. So the duke bought some strong poison, the composition of which he describes at length, and it was duly administered. But Gennaro, the intended victim, had just eaten cabbage dressed in oil, which is said to have acted as an antidote, and so he lived after all.

CONCERNING ARSENIC

ARSENIC has, perhaps, been more frequently used than any other poison for criminal purposes. It was known to the ancient Greeks in the form of the yellow sulphide, commonly called orpiment. It is found in Greece and Hungary. Its bright yellow colour caused many of the early alchemists to consider it the key to the Philosopher's Stone, and this is said to be grounded on some enigmatical verse in the Sibylline oracles. The Emperor Caligula, according to Pliny, ordered a great quantity of orpiment to be melted and manipulated, so that the gold it was supposed to contain might be extracted from it.

Arsenic is the agent most commonly employed for criminal purposes in India, doubtless because it can be both easily and cheaply obtained. The reports of the analyst to the Bombay Government throw considerable light on the methods pursued by Indian poisoners. The poison is usually given in sweetmeats, and generally by a "strange woman," who has been met in the street and who mysteriously disappears. This "strange woman" is found in every analyst's report for the past twenty years, and under much the same circumstances. Most of the cases are typical of the people among whom they occur, as, for instance, the following:

"In a Scinde district a man went into a shop one day and entered into friendly conversation with a stranger he met there. On parting, by way of thanking him, the stranger presented him with some sweets for distribution among his friends. The result was that five men and a boy were poisoned, and the obliging stranger has never been heard of since."

The professional poisoner in India--for there are many such--is rarely caught or even suspected. In a large number of cases, crimes of this kind are taken little notice of by the community; and sometimes the poisoner apparently thinks nothing of poisoning a whole family in order to make sure of his victim. The utter absence of motive in the majority of cases would point to the conclusion that they were largely the result of homicidal mania.

For more than a century after the properties of arsenic were well known, there was no certain method known for its detection, and very little advance was made until the early part of last century, when Marsh discovered his test in 1836, by means of which the minutest quantities of the poison may be detected.

It is characteristic of both arsenic and mercury, that their presence may be proved and demonstrated, even in the bones, years after they have been taken. In proof of this, the following remarkable case is given. A wealthy farmer died, and was buried in the tomb where his father had been interred thirty-five years before. An examination of certain of the bones of the father revealed particles of a metallic-looking substance, which was collected and tested, and proved to be mercury. It had thus been preserved in his body for more than the third of a century, the probability being, that he had been in the habit of taking it medicinally during the latter part of his life. Another strange case came under the notice of a Bristol chemist, in which he found abundant traces of arsenic in the bodies of several young children after they had been buried eight years.

Another instance that terminated in a less tragic manner, in which a would-be suicide was frustrated by a watchful chemist, happened some years ago.

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